Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006624 | 0.84 | NR3C2 (0.42) | NR3C2CHEK2AURKARPS6KB1IKBKB | |
| SCHEMBL21722444 | 0.81 | TDP1 (0.49) | ARNR3C2CHEK2PLK1AURKA | |
| SCHEMBL3462235 | 0.77 | PLA2G10 (0.50) | NR3C2KDM4EHPGDALDH1A1 | |
| SCHEMBL26921635 | 0.77 | AURKA (0.55) | NR3C2AURKARPS6KB1MAPK8KDM4E | |
| SCHEMBL162188 | 0.72 | L3MBTL1 (0.50) | IKBKBKDM4EHPGDALDH1A1 | |
| SCHEMBL13728292 | 0.72 | HTR2C (0.43) | NR3C2CHEK2AURKARPS6KB1MAPK8 | |
| SCHEMBL1568386 | 0.72 | MBOAT4 (0.47) | NR3C2MAOBCHEK2KDM4E | |
| SCHEMBL30006999 | 0.71 | KDM4E (0.47) | RPS6KB1KDM4EALDH1A1 | |
| SCHEMBL28492022 | 0.71 | KDM4E (0.47) | RPS6KB1KDM4EALDH1A1 | |
| SCHEMBL29519971 | 0.71 | KEAP1 (0.36) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | claimed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | claimed |