SCHEMBL21723010

SCHEMBL21723010

FC(F)(F)[C@@H](NCC1CNC1)c1ccc(Cl)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.34
CNR1 P21554 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
HTT P42858 1/20 0.33
CYP2C9 P11712 2/20 0.32
IDO1 P14902 1/20 0.32
KCNH2 Q12809 1/20 0.32
SLC6A4 P31645 3/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
SLC6A2 P23975 1/20 0.32
CYP2C19 P33261 1/20 0.32
SLC6A3 Q01959 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
P2RX7 Q99572 1/20 0.32
HTR6 P50406 1/20 0.32
EEF2K O00418 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22462886 1.00 RAB9A (0.34) RAB9ACNR1LMNATP53HTT
SCHEMBL22462907 0.84 SLC6A2 (0.37) CYP2C9KCNH2SLC6A4CYP1A2CYP3A4
SCHEMBL22462819 0.72 KDM1A (0.41) SLC6A4SLC6A2SLC6A3
SCHEMBL21722996 0.72 KDM1A (0.41) SLC6A4SLC6A2SLC6A3
SCHEMBL22462863 0.71 GRIN2B (0.41) RAB9ACYP2C9CYP3A4CYP2D6CYP2C19
SCHEMBL21723169 0.71 GRIN2B (0.41) RAB9ACYP2C9CYP3A4CYP2D6CYP2C19
SCHEMBL22462873 0.71 SLC6A2 (0.38) CYP2C9IDO1KCNH2SLC6A4CYP1A2
SCHEMBL22462955 0.70 CHRNB2 (0.36) CYP2C9IDO1KCNH2SLC6A4SLC6A2
SCHEMBL22462816 0.68 SLC6A4 (0.42) SLC6A4HTR6CHRNB2CHRNA4
SCHEMBL11457188 0.64 TP53 (0.50) LMNATP53HTTIDO1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3837263-A1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2021-06-23 EP disclosed
EP-3837264-A1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2021-06-23 EP disclosed
WO-2020035424-A1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2020-02-20 WO disclosed
WO-2020035425-A1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2020-02-20 WO disclosed