Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MAN2A1 | Q16706 | 5/20 | 0.37 |
| ▸ | MAN1B1 | Q9UKM7 | 5/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22462819 | 1.00 | KDM1A (0.41) | KDM1AMAOBMAN2A1MAN1B1CTSL | |
| SCHEMBL22462873 | 0.86 | SLC6A2 (0.38) | CTSLCTSSCTSKSLC6A2SLC6A4 | |
| SCHEMBL22462955 | 0.85 | CHRNB2 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL22462816 | 0.83 | SLC6A4 (0.42) | SLC6A4 | |
| SCHEMBL22462907 | 0.80 | SLC6A2 (0.37) | KDM1AMAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28030149 | 0.78 | MTOR (0.50) | KDM1AMAOBMAN2A1MAN1B1SLC6A2 | |
| SCHEMBL22462886 | 0.72 | RAB9A (0.34) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21723010 | 0.72 | RAB9A (0.34) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6703486 | 0.71 | CTSL (0.41) | CTSLCTSSCTSKSLC6A2SLC6A4 | |
| SCHEMBL22016791 | 0.71 | CTSL (0.41) | CTSLCTSSCTSKSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837263-A1 | NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2021-06-23 | — | — | EP | disclosed |
| EP-3837264-A1 | NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035425-A1 | NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-02-20 | — | — | WO | disclosed |
| WO-2020035424-A1 | NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-02-20 | — | — | WO | disclosed |