Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793032 | 0.79 | KEAP1 (0.47) | MAPTKMT2AMAPK1EGFRGAA | |
| SCHEMBL13006367 | 0.76 | ADRA2C (0.56) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL20376817 | 0.72 | ADRA2C (0.51) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL2113196 | 0.71 | ADRA2C (0.50) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL173027 | 0.70 | ADRB1 (0.62) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL30656303 | 0.70 | ADRB1 (0.62) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL27762008 | 0.70 | ADRA2C (0.49) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL27762010 | 0.70 | ADRA2C (0.49) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL24227168 | 0.69 | ADRA2C (0.47) | ADRA2CDRD2DRD3MAPTKMT2A | |
| SCHEMBL11369242 | 0.69 | ADRA2C (0.47) | ADRA2CDRD2DRD3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837240-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |