Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.54 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965134 | 1.00 | PIK3CD (0.59) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL16179380 | 0.87 | BTK (0.55) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL31048540 | 0.86 | PDK2 (0.55) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL19484795 | 0.86 | BRD4 (0.51) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL30263308 | 0.85 | C1S (0.51) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL21400332 | 0.84 | BRD4 (0.50) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL3999222 | 0.84 | SMARCA2 (0.50) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL27717965 | 0.83 | BCAT2 (0.56) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL30527143 | 0.82 | SLC22A12 (0.54) | PIK3CDGRM2PDK2BTKLCK | |
| SCHEMBL3995847 | 0.82 | SLC6A3 (0.54) | PIK3CDGRM2PDK2BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837262-A1 | N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF | Amgen Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020036940-A1 | N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF | AMGEN INC. (US) | 2020-02-20 | — | — | WO | disclosed |