Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371902 | 1.00 | GPR119 (0.41) | GPR119MAPTSMN1; SMN2AGTR2HTRA1 | |
| SCHEMBL1371847 | 0.88 | CYP1A2 (0.41) | AGTR2HTRA1NR1H2NR1H3KDM4E | |
| SCHEMBL2172111 | 0.88 | CYP1A2 (0.41) | AGTR2HTRA1NR1H2NR1H3KDM4E | |
| SCHEMBL1374782 | 0.87 | KDM4E (0.38) | AGTR2HTRA1NR1H2NR1H3TDP1 | |
| SCHEMBL18301520 | 0.87 | KDM4E (0.38) | AGTR2HTRA1NR1H2NR1H3TDP1 | |
| SCHEMBL24645440 | 0.87 | ALDH1A1 (0.40) | GPR119SMN1; SMN2NR1H2NR1H3TDP1 | |
| SCHEMBL2185475 | 0.87 | TSHR (0.43) | MAPTAGTR2HTRA1NR1H2NR1H3 | |
| SCHEMBL1372212 | 0.87 | TSHR (0.43) | MAPTAGTR2HTRA1NR1H2NR1H3 | |
| SCHEMBL30882387 | 0.86 | UCHL1 (0.41) | AGTR2HTRA1NR1H2NR1H3UCHL1 | |
| SCHEMBL29202496 | 0.86 | UCHL1 (0.41) | AGTR2HTRA1NR1H2NR1H3UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |