Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.81 |
| ▸ | FLT3 | P36888 | 6/20 | 0.81 |
| ▸ | CSF1R | P07333 | 6/20 | 0.69 |
| ▸ | MET | P08581 | 7/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174633 | 0.90 | PDGFRB (0.67) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL5598429 | 0.89 | PDGFRB (0.65) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL4214384 | 0.89 | PDGFRB (0.77) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173131 | 0.88 | MET (0.64) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2174860 | 0.87 | MET (0.63) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL5598197 | 0.83 | PDGFRB (0.59) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173631 | 0.83 | KDR (0.69) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173585 | 0.81 | MET (0.70) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173815 | 0.81 | MET (0.68) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2174542 | 0.81 | PDGFRB (0.84) | KDRPDGFRBFLT3CSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | claimed |