Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.65 |
| ▸ | FLT3 | P36888 | 7/20 | 0.65 |
| ▸ | KDR | P35968 | 7/20 | 0.65 |
| ▸ | CSF1R | P07333 | 9/20 | 0.64 |
| ▸ | MET | P08581 | 7/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172536 | 0.89 | KDR (0.81) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL5598197 | 0.85 | PDGFRB (0.59) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL2174633 | 0.83 | PDGFRB (0.67) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL4214384 | 0.79 | PDGFRB (0.77) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL5598979 | 0.78 | CSF1R (0.64) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL5610715 | 0.77 | SMN1; SMN2 (0.55) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL5599019 | 0.77 | PDGFRB (0.64) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL2173131 | 0.77 | MET (0.64) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL2174860 | 0.76 | MET (0.63) | PDGFRBFLT3KDRCSF1RMET | |
| SCHEMBL4513314 | 0.75 | PDGFRB (0.65) | PDGFRBFLT3KDRCSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |