Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.60 |
| ▸ | FABP4 | P15090 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | CD40 | P25942 | 3/20 | 0.43 |
| ▸ | CD40LG | P29965 | 3/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | CHAT | P28329 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27459951 | 0.85 | TTR (0.59) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL30950399 | 0.83 | TTR (0.56) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL8514648 | 0.83 | TTR (0.56) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL2742893 | 0.81 | TTR (0.62) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL21857967 | 0.80 | TTR (0.54) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL23178061 | 0.79 | TTR (0.64) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL6911279 | 0.79 | TTR (0.64) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL1742117 | 0.78 | TTR (0.59) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL18769044 | 0.77 | TTR (0.60) | TTRFABP4CCNA2CDK2MAPK14 | |
| SCHEMBL18768617 | 0.76 | TTR (0.56) | TTRFABP4CCNA2CDK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | UNIVERSITY OF MIAMI (US) | 2020-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562848-B2 | Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same | CD40, TNFRSF9, TNFRSF1A | TTR 2920/4885FABP4 3476/4885CCNA2 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.