Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17065065 | 0.78 | MAPT (0.51) | MAPTALDH1A1MAPK1KMT2ACHRNB2 | |
| SCHEMBL21919220 | 0.74 | SIGMAR1 (0.43) | CYP2A6GSK3B | |
| SCHEMBL27406528 | 0.72 | HDAC3 (0.40) | ALDH1A1KMT2ASMN1; SMN2KDM4EMPO | |
| SCHEMBL8429957 | 0.71 | TDP1 (0.52) | ALDH1A1MAPK1KMT2ATSHRSMN1; SMN2 | |
| Hexane SCHEMBL20446667 | 0.70 | NAAA (0.47) | MAPTALDH1A1MAPK1KMT2ACYP1A2 | |
| SCHEMBL28233818 | 0.68 | MAPT (0.40) | MAPTALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL21919085 | 0.67 | KMT2A (0.41) | MAPTKMT2ASMN1; SMN2GSK3B | |
| SCHEMBL22056712 | 0.67 | NAPRT (0.41) | MAPTALDH1A1KMT2AKDM4EMPO | |
| SCHEMBL27761579 | 0.67 | KDM4E (0.50) | MAPTALDH1A1MAPK1KMT2ATSHR | |
| SCHEMBL18623202 | 0.66 | MAPT (0.39) | MAPTALDH1A1MAPK1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562850-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2020-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562850-B2 | Human plasma kallikrein inhibitors | KLKB1, KLK5, KLK1 | MAPT 2812/4885ALDH1A1 1419/4885MAPK1 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.