Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019038 | 0.84 | MAPT (0.48) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL677963 | 0.82 | MAPT (0.46) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL527583 | 0.81 | MAPT (0.50) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL1262317 | 0.79 | MAPT (0.48) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL12727277 | 0.79 | ALDH1A1 (0.43) | HPGDLMNAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17319344 | 0.79 | MAPT (0.48) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL16659380 | 0.78 | MAPT (0.52) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL50646 | 0.77 | MAPT (0.68) | MAPTRAB9AHPGDLMNAKMT2A | |
| SCHEMBL13240309 | 0.77 | CA1 (0.55) | MAPTRAB9AKMT2AL3MBTL1MEN1 | |
| SCHEMBL9683939 | 0.76 | MAPT (0.50) | MAPTRAB9AHPGDLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3094626-B1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2020-02-19 | — | — | EP | disclosed |