SCHEMBL21728894

SCHEMBL21728894

Nc1ccc(C2CC2(F)F)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.43
TSHR P16473 4/20 0.43
ALDH1A1 P00352 2/20 0.42
MAPK1 P28482 1/20 0.42
ESR2 Q92731 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
CASP1 P29466 1/20 0.36
RECQL P46063 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24987701 0.75 LMNA (0.33) SLC6A2SLC6A4SLC6A3
Methyl Alcohol SCHEMBL9580463 0.74 SLC6A2 (0.41) BACE1SLC6A2SLC6A4SLC6A3TAAR1
SCHEMBL854929 0.74 CYP3A4 (0.48) CYP3A4TSHRALDH1A1MAPK1ESR2
SCHEMBL14934980 0.73 MAP3K12 (0.37)
SCHEMBL30695906 0.73 DDB1 (0.40) CYP3A4ALDH1A1MAOAMAOBKDM1A
Hydrochloric Acid SCHEMBL31645588 0.71 KDM1A (0.39) ALDH1A1MAOAMAOBKDM1A
SCHEMBL3781164 0.71 SLC6A2 (0.50) CYP3A4TSHRALDH1A1MAPK1ESR2
SCHEMBL3789570 0.71 SLC6A2 (0.46) CYP3A4TSHRALDH1A1MAPK1ESR2
SCHEMBL3786337 0.69 SLC6A2 (0.49) CYP3A4TSHRALDH1A1MAPK1BACE1
SCHEMBL27191319 0.68 RECQL (0.36) RECQLIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2773616-B1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-02-19 EP disclosed