Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732277 | 0.87 | NTRK1 (0.51) | JAK2NTRK1 | |
| SCHEMBL21732278 | 0.81 | PIK3C3 (0.43) | SMN1; SMN2SCN9APIK3C3MAOAMAOB | |
| SCHEMBL21723213 | 0.81 | PIK3C3 (0.43) | SMN1; SMN2SCN9APIK3C3MAOAMAOB | |
| SCHEMBL21732102 | 0.80 | NTRK1 (0.44) | JAK2NTRK1MAOAMAOB | |
| SCHEMBL21732197 | 0.79 | NTRK1 (0.39) | JAK2NTRK1 | |
| SCHEMBL21732201 | 0.72 | HDAC6 (0.44) | SMN1; SMN2PIK3C3NTRK1MAOAMAOB | |
| SCHEMBL21732101 | 0.68 | JAK2 (0.38) | JAK2NTRK1MAOAMAOB | |
| SCHEMBL24775407 | 0.68 | CHRNB2 (0.64) | ALDH1A1 | |
| SCHEMBL13162079 | 0.68 | CHRNB2 (0.64) | ALDH1A1 | |
| SCHEMBL21723222 | 0.67 | NTRK1 (0.48) | PIK3C3JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |