Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732254 | 0.92 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL21732206 | 0.84 | RORC (0.37) | RORC | |
| SCHEMBL21732214 | 0.83 | RORC (0.36) | NTRK1RORC | |
| SCHEMBL21732119 | 0.83 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL21732179 | 0.82 | PIK3C3 (0.36) | NTRK1EP300CREBBPRORCSCN9A | |
| SCHEMBL21732265 | 0.82 | RORC (0.41) | RORCSCN9A | |
| SCHEMBL21732208 | 0.82 | RORC (0.39) | NTRK1RORC | |
| SCHEMBL21732177 | 0.82 | NTRK1 (0.42) | NTRK1 | |
| SCHEMBL21732188 | 0.81 | RORC (0.38) | RORC | |
| SCHEMBL21732266 | 0.80 | RORC (0.38) | NTRK1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |