Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22750950 | 0.82 | MAPT (0.57) | MAPTTP53MAPK1 | |
| SCHEMBL2173220 | 0.75 | GPBAR1 (0.46) | MAPTTP53 | |
| SCHEMBL2175482 | 0.71 | ROCK2 (0.49) | MAPTTP53NPC1MAPK1 | |
| SCHEMBL5698468 | 0.68 | CDK2 (0.54) | MAPTTP53 | |
| SCHEMBL13545789 | 0.65 | GAA (0.77) | MAPTNPC1 | |
| SCHEMBL3461102 | 0.65 | NPC1 (0.70) | TP53NPC1 | |
| SCHEMBL2171642 | 0.65 | MAPT (0.67) | MAPTTP53NPC1MAPK1 | |
| SCHEMBL5945685 | 0.64 | RAB9A (0.60) | NPC1MAPK3MAPK1 | |
| SCHEMBL5057266 | 0.64 | CNR1 (0.77) | MAPTTP53CNR2CNR1 | |
| SCHEMBL5332860 | 0.64 | NPC1 (0.72) | NPC1MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |