Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173538 | 0.80 | TP53 (0.44) | ROCK2MAPTTP53GAAALDH1A1 | |
| SCHEMBL2175753 | 0.76 | MAPT (0.47) | ROCK2NPC1MAPTTP53POLB | |
| SCHEMBL2171311 | 0.75 | ALDH1A1 (0.45) | ROCK2RAB9ANPC1MAPTTP53 | |
| SCHEMBL2548371 | 0.75 | ALDH1A1 (0.48) | RAB9ANPC1MAPTTP53POLB | |
| SCHEMBL2173329 | 0.75 | GPBAR1 (0.47) | MAPTTP53POLBKMT2AALDH1A1 | |
| SCHEMBL2171582 | 0.72 | MAPT (0.46) | ROCK2RAB9ANPC1MAPTTP53 | |
| SCHEMBL2171482 | 0.72 | KDM4E (0.59) | RAB9ANPC1POLBKMT2AGAA | |
| SCHEMBL2173228 | 0.71 | MAPT (0.57) | NPC1MAPTTP53MAPK1 | |
| SCHEMBL30290797 | 0.71 | KDM4E (0.51) | RAB9ANPC1MAPTPOLBPARP1 | |
| SCHEMBL2548352 | 0.70 | TP53 (0.67) | MAPTTP53POLBGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |