Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.35 |
| ▸ | RORC | P51449 | 10/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732284 | 0.88 | RORC (0.49) | JAK2NTRK1RORC | |
| SCHEMBL21732296 | 0.86 | RORC (0.37) | JAK2NTRK1RORC | |
| SCHEMBL21732198 | 0.83 | NTRK1 (0.37) | JAK2NTRK1RORC | |
| SCHEMBL21732072 | 0.80 | NTRK1 (0.41) | JAK2NTRK1 | |
| SCHEMBL21732225 | 0.77 | RORC (0.37) | JAK2NTRK1RORC | |
| SCHEMBL21732220 | 0.74 | NTRK1 (0.44) | JAK2NTRK1 | |
| SCHEMBL21732295 | 0.74 | RORC (0.51) | RORC | |
| SCHEMBL21732282 | 0.72 | NTRK1 (0.40) | JAK2NTRK1SLC6A9NR3C2 | |
| SCHEMBL21723531 | 0.68 | NTRK1 (0.40) | JAK2NTRK1SLC6A9NR3C2 | |
| SCHEMBL21723160 | 0.67 | HDAC1 (0.40) | JAK2NTRK1SLC6A9NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |