Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 7/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30216229 | 1.00 | ALDH1A1 (0.55) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL30216257 | 0.84 | ALDH1A1 (0.56) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL21789371 | 0.84 | ALDH1A1 (0.56) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL21733289 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL30216252 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL18375758 | 0.81 | SMN1; SMN2 (0.55) | JAK2JAK1TYK2 | |
| SCHEMBL21774861 | 0.79 | SMYD3 (0.50) | HDAC11 | |
| SCHEMBL21774864 | 0.79 | SMYD3 (0.50) | HDAC11 | |
| SCHEMBL29591197 | 0.78 | ALDH1A1 (0.59) | ALDH1A1GAATSHREPHX1JAK2 | |
| SCHEMBL30151694 | 0.78 | ALDH1A1 (0.59) | ALDH1A1GAATSHREPHX1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572362-B2 | Pyrrolo[1,2-b]pyridazine derivatives | GILEAD SCIENCES, INC. (US) | 2023-02-07 | — | — | US | disclosed |
| US-20200071333-A1 | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-03-05 | — | — | US | disclosed |
| WO-2020036979-A1 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES AS IRAK4 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572362-B2 | Pyrrolo[1,2-b]pyridazine derivatives | CYP11B2, CYP11B1, DHPS | ALDH1A1 444/4885GAA 660/4885TSHR 2596/4885 |
| US-20200071333-A1 | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES | CYP11B2, CYP11B1, DHPS | ALDH1A1 444/4885GAA 660/4885TSHR 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.