Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26268266 | 0.93 | TP53 (0.32) | TP53LTB4R2ALDH1A1HCRTR2 | |
| SCHEMBL21733838 | 0.93 | TP53 (0.32) | TP53LTB4R2ALDH1A1HCRTR2 | |
| SCHEMBL26269144 | 0.85 | TP53 (0.31) | TP53LTB4R2ALDH1A1 | |
| SCHEMBL28493072 | 0.84 | TSPO (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL21733488 | 0.83 | TP53 (0.33) | TP53LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21733469 | 0.83 | HCRTR2 (0.31) | TP53LTB4R2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL24854884 | 0.82 | KDM4E (0.32) | ALDH1A1KDM4EHPGD | |
| SCHEMBL21733767 | 0.82 | TP53 (0.32) | TP53LMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26268592 | 0.82 | ALDH1A1 (0.34) | TP53LTB4R2LMNACACNA1SALDH1A1 | |
| SCHEMBL21733835 | 0.81 | MAPT (0.37) | ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |