Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.54 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21734112 | 0.88 | KRAS (0.55) | KRASSOS1 | |
| SCHEMBL21733774 | 0.83 | KRAS (0.53) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL23645699 | 0.82 | KRAS (0.54) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21733776 | 0.79 | KRAS (0.51) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL24543009 | 0.76 | KRAS (0.44) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21786275 | 0.75 | KRAS (0.69) | KRASSOS1 | |
| SCHEMBL22010615 | 0.74 | KRAS (0.63) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL30188591 | 0.74 | KRAS (0.73) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL26016793 | 0.74 | KRAS (0.70) | KRASSOS1 | |
| SCHEMBL31344949 | 0.73 | KRAS (0.88) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |