Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24682880 | 0.87 | HTR2A (0.42) | HTR2AHTR2CHTR2B | |
| SCHEMBL12633574 | 0.83 | CES2 (0.44) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL25888600 | 0.83 | CES2 (0.44) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL10190840 | 0.83 | CES2 (0.44) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL16002846 | 0.81 | PTPN5 (0.42) | HDAC4HTR2AHTR2CHTR2B | |
| SCHEMBL21739867 | 0.80 | AOC3 (0.41) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL4661201 | 0.80 | HDAC4 (0.43) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL13959433 | 0.78 | CES2 (0.34) | IDO1TDO2CES2CES1 | |
| SCHEMBL179253 | 0.78 | ACHE (0.48) | HDAC4HDAC7HDAC5IDO1TDO2 | |
| SCHEMBL792296 | 0.78 | ACHE (0.48) | HDAC4HDAC7HDAC5IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |