Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25888600 | 0.84 | CES2 (0.44) | HDAC4HDAC7HDAC5HSD11B1CES2 | |
| SCHEMBL12633574 | 0.84 | CES2 (0.44) | HDAC4HDAC7HDAC5HSD11B1CES2 | |
| SCHEMBL10190840 | 0.84 | CES2 (0.44) | HDAC4HDAC7HDAC5HSD11B1CES2 | |
| SCHEMBL21739802 | 0.80 | HDAC4 (0.42) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL6272077 | 0.77 | HDAC4 (0.40) | HDAC4HDAC7HDAC5HSD11B1CES2 | |
| SCHEMBL213645 | 0.75 | CES2 (0.52) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL14088061 | 0.75 | CES2 (0.52) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL16847361 | 0.75 | HSD11B1 (0.38) | HDAC4HDAC7HDAC5HSD11B1IDO1 | |
| SCHEMBL17086713 | 0.75 | HSD11B1 (0.38) | HDAC4HDAC7HDAC5HSD11B1IDO1 | |
| SCHEMBL8053971 | 0.75 | HSD11B1 (0.38) | HDAC4HDAC7HDAC5HSD11B1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682105-A4 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1682105-A2 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005048932-A2 | N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-02 | — | — | WO | disclosed |