Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL2174016 | 1.00 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| SCHEMBL2978516 | 0.88 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| SCHEMBL110365 | 0.88 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| SCHEMBL943620 | 0.88 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL2173176 | 0.87 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Bromide SCHEMBL2177190 | 0.87 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL2175073 | 0.87 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Bromide SCHEMBL2177195 | 0.87 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL2520909 | 0.87 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 | |
| Sulfuric Acid SCHEMBL2171810 | 0.86 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247578-B2 | Process for production of aralkyloxypyrrolidine derivative | KANEKA CORPORATION (JP) | 2012-08-21 | — | — | US | disclosed |
| US-20110224444-A1 | PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE | KANEKA CORPORATION (JP) | 2011-09-15 | — | — | US | disclosed |
| US-7973176-B2 | Process for production of aralkyloxypyrrolidine derivative | KANEKA CORPORATION (JP) | 2011-07-05 | — | — | US | disclosed |
| EP-1947083-B1 | PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE | KANEKA CORP (JP) | 2010-11-10 | — | — | EP | disclosed |
| US-20080306283-A1 | Process For Production of Aralkyloxypyrrolidine Derivative | KANEKA CORPORATION (JP) | 2008-12-11 | — | — | US | disclosed |
| EP-1947083-A1 | PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE | Kaneka Corporation (JP) | 2008-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306283-A1 | Process For Production of Aralkyloxypyrrolidine Derivative | HPD, HAAO, ARL1 | SLC6A2 2188/4885SLC6A4 1613/4885SLC6A3 1495/4885 |
| US-20110224444-A1 | PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE | HPD, HAAO, ARL1 | SLC6A2 2188/4885SLC6A4 1613/4885SLC6A3 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.