Naphthalene

Naphthalene

SCHEMBL2174111

C1CCOC1.[Li].c1ccc2ccccc2c1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
CYP2A6 P11509 1/20 0.47
ALOX12 P18054 1/20 0.47
LMNA P02545 3/20 0.42
CRHBP P24387 2/20 0.42
CRHR2 Q13324 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
HTT P42858 1/20 0.42
POLB P06746 1/20 0.37
ITGB2 P05107 1/20 0.35
ICAM1 P05362 1/20 0.35
ITGAL P20701 1/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
PKM P14618 1/20 0.33
TSHR P16473 1/20 0.33
AKR1C3 P42330 1/20 0.33
PRKDC P78527 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL10617947 0.97 ALDH1A1 (0.50) ALDH1A1CYP2A6ALOX12LMNACRHBP
Naphthalene SCHEMBL2174108 0.94 ALDH1A1 (0.47) ALDH1A1CYP2A6ALOX12LMNACRHBP
Anthracene SCHEMBL1255911 0.86 ALDH1A1 (0.44) ALDH1A1CYP2A6ALOX12LMNACRHBP
Naphthalene SCHEMBL9860278 0.84 CYP2A6 (0.57) ALDH1A1CYP2A6ALOX12LMNACRHBP
Naphthalene SCHEMBL2321089 0.84 CYP2A6 (0.57) ALDH1A1CYP2A6ALOX12LMNACRHBP
Anthracene SCHEMBL3704152 0.83 ALDH1A1 (0.42) ALDH1A1CYP2A6ALOX12LMNACRHBP
Naphthalene SCHEMBL2464187 0.81 CYP2A6 (0.61) ALDH1A1CYP2A6ALOX12LMNACRHBP
Naphthalene SCHEMBL28298001 0.81 CYP2A6 (0.61) ALDH1A1CYP2A6ALOX12LMNACRHBP
Pyrene SCHEMBL28260906 0.78 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2MEN1KMT2ATSHR
Chrysene SCHEMBL8740435 0.78 HPRT1 (0.64) ALDH1A1CYP2A6LMNAKMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2512979-A2 HYDROGEN STORAGE AND/OR GENERATION California Institute of Technology (US) 2012-10-24 EP disclosed
US-20110171119-A1 HYDROGEN STORAGE AND/OR GENERATION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2011-07-14 US disclosed
WO-2011081949-A2 HYDROGEN STORAGE AND/OR GENERATION CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2011-07-07 WO disclosed