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SCHEMBL21743068

SCHEMBL21743068

CC1(O)CCC(CS(=O)(=O)c2ccc(-c3ccc(Cl)cc3Cl)cc2)CC1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 3/20 0.45
▸ PSEN1 P49768 4/20 0.41
▸ PSEN2 P49810 4/20 0.41
▸ APH1B Q8WW43 4/20 0.41
▸ NCSTN Q92542 4/20 0.41
▸ APH1A Q96BI3 4/20 0.41
▸ PSENEN Q9NZ42 4/20 0.41
▸ LGMN Q99538 1/20 0.40
▸ DAGLA Q9Y4D2 5/20 0.39
▸ HSD11B1 P28845 1/20 0.39
▸ PTGDR2 Q9Y5Y4 1/20 0.38
▸ RORC P51449 1/20 0.38
▸ DAGLB Q8NCG7 2/20 0.38
▸ SRD5A2 P31213 1/20 0.38
▸ CRBN Q96SW2 1/20 0.37
▸ CNR1 P21554 1/20 0.36
▸ CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21743118 1.00 PTGS2 (0.45) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL21743059 1.00 PTGS2 (0.45) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL26882390 0.91 PTGS2 (0.46) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL21743183 0.86 RORC (0.44) LGMNRORC
SCHEMBL21743185 0.86 TRPV4 (0.39) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL21743119 0.86 TRPV4 (0.39) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL31245790 0.86 TRPV4 (0.39) PTGS2PSEN1PSEN2APH1BNCSTN
SCHEMBL21742961 0.86 RORC (0.44) LGMNRORC
SCHEMBL21743061 0.86 RORC (0.44) LGMNRORC
SCHEMBL21743056 0.86 TRPV4 (0.39) PTGS2PSEN1PSEN2APH1BNCSTN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3837244-B1 1-METHYL-4-[(4-PHENYLPHENYL)SULFONYLMETHYL]CYCLOHEXYANOL AND 1-METHYL-4-[[4-(2-PYRIDYL)PHENYL]SULFONYLMETHYL]CYCLOHEXANOL COMPOUNDS AND THEIR THERAPEUTIC USE ISTESSO THERAPEUTICS LTD (GB) 2025-05-14 — — EP disclosed
US-12240814-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use ISTESSO THERAPEUTICS LIMITED (GB) 2025-03-04 — — US disclosed
US-20240182418-A1 1-Methyl-4-[(4-Phenylphenyl)Sulfonylmethyl]Cyclohexyanol And 1-Methyl-4-[[4-(2-Pyridyl)Phenyl]Sulfonylmethyl]Cyclohexanol Compounds and Their Therapeutic Use Modern Biosciences Limited (GB) 2024-06-06 — — US disclosed
US-11834414-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use Modern Biosciences Limited (GB) 2023-12-05 — — US disclosed
US-11834414-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use Modern Biosciences Limited (GB) 2023-12-05 — — US disclosed
US-11834414-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use Modern Biosciences Limited (GB) 2023-12-05 — — US disclosed
US-20220363642-A1 1-METHYL-4-[(4-PHENYLPHENYL)SULFONYLMETHYL]CYCLOHEXYANOL AND 1-METHYL-4-[[4-(2-PYRIDYL)PHENYL]SULFONYLMETHYL]CYCLOHEXANOL COMPOUNDS AND THEIR THERAPEUTIC USE ISTESSO THERAPEUTICS LIMITED (GB) 2022-11-17 — — US disclosed
CN-112805270-A 1-methyl-4- [ (4-phenylphenyl) sulfonylmethyl ] cyclohexanol and 1-methyl-4- [ [4- (2-pyridinyl) phenyl ] sulfonylmethyl ] cyclohexanol compounds and therapeutic uses thereof 现代生物科学有限公司 2021-05-14 — — CN disclosed
WO-2020035560-A1 1-METHYL-4-[(4-PHENYLPHENYL)SULFONYLMETHYL]CYCLOHEXYANOL AND 1-METHYL-4-[[4-(2-PYRIDYL)PHENYL]SULFONYLMETHYL]CYCLOHEXANOL COMPOUNDS AND THEIR THERAPEUTIC USE Modern Biosciences Limited (GB) 2020-02-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220363642-A1 1-METHYL-4-[(4-PHENYLPHENYL)SULFONYLMETHYL]CYCLOHEXYANOL AND 1-METHYL-4-[[4-(2-PYRIDYL)PHENYL]SULFONYLMETHYL]CYCLOHEXANOL COMPOUNDS AND THEIR THERAPEUTIC USE MALT1, BCL3, MCL1 PTGS2 545/4885PSEN1 630/4885PSEN2 792/4885
US-11834414-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use MALT1, BCL3, MCL1 PTGS2 545/4885PSEN1 630/4885PSEN2 792/4885
US-12240814-B2 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use MALT1, BCL3, MCL1 PTGS2 545/4885PSEN1 630/4885PSEN2 792/4885
US-20240182418-A1 1-Methyl-4-[(4-Phenylphenyl)Sulfonylmethyl]Cyclohexyanol And 1-Methyl-4-[[4-(2-Pyridyl)Phenyl]Sulfonylmethyl]Cyclohexanol Compounds and Their Therapeutic Use MALT1, BCL3, MCL1 PTGS2 545/4885PSEN1 630/4885PSEN2 792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.