Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 15/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 9/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.60 |
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31653974 | 1.00 | DPP7 (1.00) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL28997417 | 1.00 | DPP7 (1.00) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL21746987 | 0.84 | DPP9 (1.00) | DPP7DPP8DPP9DPP4 | |
| SCHEMBL4775626 | 0.80 | DPP8 (0.67) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL4775624 | 0.80 | DPP8 (0.67) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL20570474 | 0.79 | HDAC8 (0.69) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL27431494 | 0.78 | DPP8 (0.63) | DPP7DPP8DPP9 | |
| SCHEMBL27726212 | 0.78 | DPP8 (0.63) | DPP7DPP8DPP9 | |
| SCHEMBL4773106 | 0.78 | DPP8 (0.63) | DPP7DPP8DPP9HDAC8DPP4 | |
| SCHEMBL4773123 | 0.78 | DPP8 (0.63) | DPP7DPP8DPP9HDAC8DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372372-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | TRUSTEES OF TUFTS COLLEGE | 2023-11-23 | — | — | US | disclosed |
| US-20230372372-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | TRUSTEES OF TUFTS COLLEGE | 2023-11-23 | — | — | US | disclosed |
| US-11559537-B2 | Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists | TRUSTEES OF TUFTS COLLEGE (US) | 2023-01-24 | — | — | US | disclosed |
| CN-108136025-B | A novel method of treating cancer using immunomodulation | 比奥克斯塞尔医疗股份有限公司 | 2022-09-06 | — | — | CN | disclosed |
| US-20200054655-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | TRUSTEES OF TUFTS COLLEGE | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11559537-B2 | Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists | CASP1, CASP2, APAF1 | DPP7 910/4885DPP8 904/4885DPP9 1286/4885 |
| US-20230372372-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | CASP1, CASP2, APAF1 | DPP7 910/4885DPP8 904/4885DPP9 1286/4885 |
| US-20200054655-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | CASP1, CASP2, APAF1 | DPP7 910/4885DPP8 904/4885DPP9 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.