Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.60 |
| ▸ | GLUL | P15104 | 1/20 | 0.47 |
| ▸ | BHMT | Q93088 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL508141 | 0.91 | OTC (0.62) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL11738414 | 0.91 | OTC (0.62) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL508142 | 0.91 | OTC (0.62) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL11738420 | 0.91 | OTC (0.62) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL11670280 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL19622767 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL29038535 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL20531891 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL29089653 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 | |
| Arginine SCHEMBL11670283 | 0.89 | OTC (0.60) | OTCGLULDDAH1GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520432-B | Optically active 2-amino-phosphonoalkanoic acid, optically active 2-amino-phosphonoalkanoic acid salt and hydrate thereof | 株式会社NAHLS | 2022-08-02 | — | — | CN | disclosed |
| US-20220135603-A1 | OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE | NAHLS CORPORATION CO., LTD. (JP) | 2022-05-05 | — | — | US | disclosed |
| US-11220521-B2 | Optically-active 2-amino-phosphonoalkane acid, optically-active 2-amino-phosphonoalkane acid salt, and hydrates of these | NAHLS CORPORATION CO., LTD. (JP) | 2022-01-11 | — | — | US | disclosed |
| US-20200131207-A1 | OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINOPHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE | NAHLS CORPORATION CO., LTD. (JP) | 2020-04-30 | — | — | US | disclosed |
| EP-3613750-A1 | OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE | Kyoto University (JP) | 2020-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135603-A1 | OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE | AASDHPPT, PHYKPL, PKD2 | OTC 2522/4885GLUL 104/4885BHMT 3130/4885 |
| US-11220521-B2 | Optically-active 2-amino-phosphonoalkane acid, optically-active 2-amino-phosphonoalkane acid salt, and hydrates of these | AASDHPPT, PHYKPL, PKD2 | OTC 2522/4885GLUL 104/4885BHMT 3130/4885 |
| US-20200131207-A1 | OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINOPHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE | AASDHPPT, PHYKPL, PHOSPHO1 | OTC 2640/4885GLUL 186/4885BHMT 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.