Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981063 | 0.83 | GSR (0.38) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL9980973 | 0.83 | FAAH (0.39) | KMT2AALDH1A1LMNATP53PDE10A | |
| SCHEMBL9980961 | 0.82 | PDE10A (0.38) | KDM4EALDH1A1LMNAPDE4BPDE10A | |
| SCHEMBL9981109 | 0.81 | HRH1 (0.34) | KDM4EALDH1A1LMNAMPOPDE4B | |
| SCHEMBL21748380 | 0.77 | CYP1A2 (0.41) | POLBMEN1KMT2APABPC1TP53 | |
| SCHEMBL9981190 | 0.75 | GABRP (0.45) | KDM4EALDH1A1LMNAPDE4BPDE10A | |
| SCHEMBL21748381 | 0.69 | PDE10A (0.40) | POLBMEN1KMT2APABPC1CMA1 | |
| SCHEMBL9981178 | 0.66 | HRH1 (0.46) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1701632 | 0.64 | SMN1; SMN2 (0.44) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL9980963 | 0.63 | FAAH (0.39) | POLBMEN1KMT2APABPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |