SCHEMBL2174857

SCHEMBL2174857

Cc1cc(NC(=O)OC(C)(C)C)no1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.56
ALDH1A1 P00352 3/20 0.53
EGFR P00533 1/20 0.53
GAA P10253 1/20 0.53
NPC1 O15118 9/20 0.53
RAB9A P51151 9/20 0.53
TSHR P16473 2/20 0.50
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
PKM P14618 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.49
TP53 P04637 2/20 0.49
KDM4E B2RXH2 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 2/20 0.48
POLB P06746 1/20 0.48
CYP3A4 P08684 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3094315 0.83 ALDH1A1 (0.57) MAPTALDH1A1EGFRGAAKMT2A
SCHEMBL11643675 0.82 MAPT (0.62) MAPTALDH1A1EGFRGAANPC1
SCHEMBL16943756 0.82 EGFR (0.59) MAPTEGFRNPC1RAB9ATSHR
SCHEMBL25170938 0.81 HCAR2 (0.46) EGFRNPC1RAB9AKMT2AMEN1
SCHEMBL17825139 0.78 NR1H4 (0.47) EGFRNPC1RAB9A
SCHEMBL12491763 0.78 NR1H4 (0.47) ALDH1A1EGFRGAANPC1RAB9A
SCHEMBL9165074 0.78 NPC1 (0.71) MAPTALDH1A1EGFRGAANPC1
SCHEMBL6621460 0.77 NR1H4 (0.46) EGFRNPC1RAB9AKMT2AMEN1
SCHEMBL1888991 0.76 MAPT (0.69) MAPTALDH1A1EGFRGAANPC1
SCHEMBL20355063 0.76 LCK (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038863-A1 INDOLE AND PYRROLOYPYRIDINE DERIVATIVES AS GPR17 MODULATORS BIOGEN MA INC. (US) 2025-02-20 WO disclosed
EP-2185549-B1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS INC (KY) 2018-10-03 EP disclosed
CN-101798302-B Method and technology for synthesizing and producing antibiotic medicament namely 1-(o-fluorophenyl) dihydropyridone MICURX SHANGHAI PHARMACEUTICAL INC 2014-11-05 CN disclosed
US-20120190713-A1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS GORDEEV MIKHAIL FEDOROVICH (US) 2012-07-26 US disclosed
US-20120190713-A1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS GORDEEV MIKHAIL FEDOROVICH (US) 2012-07-26 US disclosed
US-8178683-B2 Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections MICURX PHARMACEUTICALS, INC. (KY) 2012-05-15 US disclosed
US-8178683-B2 Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections MICURX PHARMACEUTICALS, INC. (KY) 2012-05-15 US disclosed
US-8178683-B2 Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections MICURX PHARMACEUTICALS, INC. (KY) 2012-05-15 US disclosed
US-20110166124-A1 TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE MCCORMICK KEVIN D 2011-07-07 US disclosed
US-7973164-B2 Quinoline derivatives ASTRAZENECA AB (SE) 2011-07-05 US disclosed
US-20090076074-A1 QUINOLINE DERIVATIVES ASTRAZENECA AB (SE) 2009-03-19 US disclosed
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) 2009-02-19 US disclosed
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) 2009-02-19 US disclosed
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) 2009-02-19 US disclosed
US-20080318977-A1 Condensed Pyridines as Kinase Inhibitors PALAU PHARMA, S.A. (ES) 2008-12-25 US disclosed
EP-1996588-A1 NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS Torrent Pharmaceuticals Ltd (IN) 2008-12-03 EP disclosed
EP-1833828-A2 CONDENSED PYRIDINES AS KINASE INHIBITORS Palau Pharma, S.A. (ES) 2007-09-19 EP disclosed
WO-2007100295-A1 NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS TORRENT PHARMACEUTICALS LTD (IN) 2007-09-07 WO disclosed
WO-2007100295-A1 NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS TORRENT PHARMACEUTICALS LTD (IN) 2007-09-07 WO disclosed
WO-2006013095-A2 CONDENSED PYRIDINES AS KINASE INHIBITORS PALAU PHARMA, S.A. (ES) 2006-02-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190713-A1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS OXA1L, OGFOD1, OLA1 MAPT 4287/4885ALDH1A1 1556/4885EGFR 1728/4885
US-20080318977-A1 Condensed Pyridines as Kinase Inhibitors MAPK1, MAP4K2, MAP3K1 MAPT 1329/4885ALDH1A1 2298/4885EGFR 1270/4885
US-20090048305-A1 Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections OXA1L, OGFOD1, OLA1 MAPT 4287/4885ALDH1A1 1556/4885EGFR 1728/4885
US-20090076074-A1 QUINOLINE DERIVATIVES RECQL, NQO2, CCNA1 MAPT 2696/4885ALDH1A1 887/4885EGFR 2480/4885
US-20110166124-A1 TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE GPR119, TRPV1, NR3C2 MAPT 2451/4885ALDH1A1 994/4885EGFR 3955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.