SCHEMBL2174903

SCHEMBL2174903

Brc1ccccc1/C=C/c1ccncc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.46
KDM4E B2RXH2 2/20 0.46
HSD17B10 Q99714 1/20 0.46
LMNA P02545 1/20 0.46
HSD11B1 P28845 1/20 0.46
NPC1 O15118 5/20 0.43
GFER P55789 1/20 0.43
CHRNA7 P36544 1/20 0.42
KDM1A O60341 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
RAB9A P51151 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALOX15 P16050 1/20 0.41
CASP1 P29466 1/20 0.41
HBB P68871 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30639253 1.00 MAPT (0.46) MAPTKDM4EHSD17B10LMNAHSD11B1
SCHEMBL2173027 1.00 MAPT (0.46) MAPTKDM4EHSD17B10LMNAHSD11B1
SCHEMBL3328961 0.85 HSD11B1 (0.54) HSD11B1NPC1CHRNA7RAB9AMEN1
SCHEMBL3328957 0.85 HSD11B1 (0.54) HSD11B1NPC1CHRNA7RAB9AMEN1
SCHEMBL9928814 0.85 MAPT (0.53) MAPTKDM4EHSD17B10LMNANPC1
SCHEMBL30364986 0.83 NFE2L2 (0.56) HSD11B1NPC1CHRNA7MEN1KMT2A
SCHEMBL6737776 0.83 NFE2L2 (0.56) HSD11B1NPC1CHRNA7MEN1KMT2A
SCHEMBL6737772 0.83 NFE2L2 (0.56) HSD11B1NPC1CHRNA7MEN1KMT2A
SCHEMBL14703725 0.83 NFE2L2 (0.56) HSD11B1NPC1CHRNA7MEN1KMT2A
SCHEMBL15271837 0.80 CCNC (0.54) MAPTKDM4EHSD17B10LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116903784-A Acrylamide copolymer and photo-crosslinking copolymer 浙江大学衢州研究院 2023-10-20 CN claimed
CN-116903784-A Acrylamide copolymer and photo-crosslinking copolymer 浙江大学衢州研究院 2023-10-20 CN disclosed
CN-116903784-A Acrylamide copolymer and photo-crosslinking copolymer 浙江大学衢州研究院 2023-10-20 CN disclosed
EP-2346332-A1 PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES Medivation Technologies, Inc. (US) 2011-07-27 EP disclosed
WO-2010051501-A1 PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES MEDIVATION TECHNOLOGIES, INC. (US) 2010-05-06 WO disclosed