Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749178 | 0.86 | NPC1 (0.57) | NPC1RAB9AALDH1A1DPP4KMT2A | |
| SCHEMBL20502590 | 0.86 | NPC1 (0.46) | NPC1RAB9AALDH1A1KMT2ATP53 | |
| SCHEMBL21749175 | 0.81 | CYP11B2 (0.46) | NPC1RAB9AALDH1A1KMT2ATP53 | |
| SCHEMBL21775448 | 0.75 | NPC1 (0.55) | NPC1RAB9AALDH1A1DPP4KMT2A | |
| SCHEMBL21749166 | 0.74 | DPP4 (0.39) | NPC1RAB9AALDH1A1DPP4DPP8 | |
| SCHEMBL21775737 | 0.74 | NPC1 (0.62) | NPC1RAB9AALDH1A1DPP4KMT2A | |
| SCHEMBL21775456 | 0.73 | NPC1 (0.57) | NPC1RAB9AALDH1A1KMT2ATP53 | |
| SCHEMBL21775459 | 0.73 | NPC1 (0.53) | NPC1RAB9AALDH1A1DPP4KMT2A | |
| SCHEMBL13977780 | 0.72 | NPC1 (0.73) | NPC1RAB9AALDH1A1DPP4KMT2A | |
| SCHEMBL21775857 | 0.72 | MAPT (0.57) | NPC1RAB9AALDH1A1DPP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10960007-B2 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives | RICHTER GEDEON NYRT. (HU) | 2021-03-30 | — | — | US | disclosed |
| US-20200061068-A1 | Pharmacologically Active Aryl-Substituted Pyrazolo[1,5-a]Pyrimidine Derivatives | RICHTER GEDEON NYRT. (HU) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200061068-A1 | Pharmacologically Active Aryl-Substituted Pyrazolo[1,5-a]Pyrimidine Derivatives | GABRA5, P2RX5, P2RY1 | NPC1 1179/4885RAB9A 988/4885ALDH1A1 585/4885 |
| US-10960007-B2 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives | GABRA5, P2RX5, P2RY1 | NPC1 1179/4885RAB9A 988/4885ALDH1A1 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.