Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 3/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13835528 | 0.80 | APP (0.41) | LMNASMN1; SMN2KDM4EALDH1A1APP | |
| SCHEMBL18205535 | 0.74 | LMNA (0.39) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13485730 | 0.72 | PDE2A (0.38) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27769272 | 0.72 | L3MBTL1 (0.44) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31043000 | 0.72 | ALDH1A1 (0.39) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15721000 | 0.72 | ALDH1A1 (0.39) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1901364 | 0.72 | LMNA (0.38) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24208587 | 0.71 | LMNA (0.36) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20267813 | 0.71 | LMNA (0.36) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7806788 | 0.70 | LMNA (0.39) | L3MBTL1LMNASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | disclosed |