⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31356397 | 0.76 | ALDH1A1 (0.42) | — | |
| SCHEMBL24188741 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL21769502 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL24192726 | 0.70 | THRB (0.43) | — | |
| SCHEMBL24408065 | 0.69 | THRB (0.40) | — | |
| SCHEMBL24193214 | 0.69 | HPGD (0.37) | — | |
| SCHEMBL21188346 | 0.63 | ALDH1A1 (0.46) | — | |
| SCHEMBL30548940 | 0.60 | — | — | |
| SCHEMBL22626700 | 0.60 | — | — | |
| SCHEMBL4896144 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112805005-B | Thyroxine receptor beta agonist compounds | 拓臻股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| EP-3840755-B1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS INC (US) | 2026-02-18 | — | — | EP | disclosed |
| US-12528791-B2 | Thyroid hormone receptor beta agonist compounds | TERNS PHARMACEUTICALS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12398127-B2 | Thyroid hormone receptor beta agonist compounds | TERNS PHARMACEUTICALS, INC. (US) | 2025-08-26 | — | — | US | disclosed |
| US-20250236615-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. | 2025-07-24 | — | — | US | disclosed |
| US-20240239761-A1 | BICYCLIC PHENOL COMPOUNDS AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2024-07-18 | — | — | US | disclosed |
| US-20240239761-A1 | BICYCLIC PHENOL COMPOUNDS AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2024-07-18 | — | — | US | disclosed |
| CN-114375193-B | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2024-05-14 | — | — | CN | disclosed |
| US-20240116912-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | TERNS PHARMACEUTICALS, INC. | 2024-04-11 | — | — | US | disclosed |
| US-20240059682-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. | 2024-02-22 | — | — | US | disclosed |
| CN-112805005-A | Thyroxine receptor beta agonist compounds | 拓臻股份有限公司 | 2021-05-14 | — | — | CN | disclosed |
| WO-2021050945-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |
| WO-2021050945-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |
| WO-2021041237-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021041237-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |
| US-10800767-B2 | Thyroid hormone receptor beta agonist compounds | Terns, Inc. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10800767-B2 | Thyroid hormone receptor beta agonist compounds | Terns, Inc. (US) | 2020-10-13 | — | — | US | disclosed |
| WO-2020041741-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2020-02-27 | — | — | WO | disclosed |
| US-20200062742-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. | 2020-02-27 | — | — | US | disclosed |
| US-20200062742-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. | 2020-02-27 | — | — | US | disclosed |