Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 0.69 |
| ▸ | CCNC | P24863 | 10/20 | 0.69 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.55 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.53 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21750400 | 0.82 | CCNC (1.00) | CDK8CCNCPDE5ACDK19MAP4K2 | |
| SCHEMBL23999973 | 0.81 | GAK (0.59) | CDK8CCNCPDE5AHTR1AADRA1D | |
| SCHEMBL21750414 | 0.78 | CCNC (0.77) | CDK8CCNCPDE5ACDK19GAK | |
| SCHEMBL22274361 | 0.78 | HTR1A (0.59) | CDK8CCNCHTR1AADRA1DADRA1A | |
| SCHEMBL21750391 | 0.77 | GAK (0.55) | CDK8CCNCPDE5AHTR1AADRA1D | |
| SCHEMBL4996776 | 0.75 | PDE5A (0.81) | CDK8CCNCPDE5ACDK19GAK | |
| SCHEMBL4142709 | 0.74 | HTR1A (0.80) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL18720521 | 0.74 | ABCB1 (0.45) | CDK8CCNC | |
| SCHEMBL18041216 | 0.74 | HTR1A (0.54) | CDK8CCNCHTR1AADRA1DADRA1A | |
| SCHEMBL981901 | 0.72 | CDK8 (0.51) | CDK8CCNCPDE5ACDK19GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12281080-B2 | Quinoline-based compounds and methods of inhibiting CDK8/19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2025-04-22 | — | — | US | disclosed |
| US-20210276956-A1 | QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2021-09-09 | — | — | US | disclosed |
| US-11014906-B2 | Quinoline-based compounds and methods of inhibiting CDK8/19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200062728-A1 | QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062728-A1 | QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19 | CDK8, CDK9, CDK19 | CDK8 1/4885CCNC 34/4885PDE5A 2042/4885 |
| US-11014906-B2 | Quinoline-based compounds and methods of inhibiting CDK8/19 | CDK8, CDK9, CDK19 | CDK8 1/4885CCNC 35/4885PDE5A 2279/4885 |
| US-12281080-B2 | Quinoline-based compounds and methods of inhibiting CDK8/19 | CDK8, CDK9, CDK19 | CDK8 1/4885CCNC 35/4885PDE5A 2279/4885 |
| US-20210276956-A1 | QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19 | CDK8, CDK9, CDK19 | CDK8 1/4885CCNC 34/4885PDE5A 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.