SCHEMBL21751459

SCHEMBL21751459

O=c1c(Cc2ccc(C(F)(F)F)o2)nc2c(Cc3ccccc3)[nH]c(-c3cccc([N+](=O)[O-])c3F)cn1-2

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.33
▸ F2 P00734 1/20 0.33
▸ C1R P00736 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ KLK3 P07288 1/20 0.33
▸ CFTR P13569 1/20 0.32
▸ PSD A5PKW4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21751334 0.88 GNRHR (0.32) KMT2A
SCHEMBL21751307 0.88 LTB4R (0.31) —
SCHEMBL21751450 0.86 CFTR (0.34) MEN1MAPTKMT2ACFTRPSD
SCHEMBL30800244 0.86 CFTR (0.34) MEN1MAPTKMT2ACFTRPSD
SCHEMBL30800167 0.86 CFTR (0.34) MEN1F2C1RMAPTKMT2A
SCHEMBL21751390 0.86 CFTR (0.34) MEN1F2C1RMAPTKMT2A
SCHEMBL21751332 0.84 — —
SCHEMBL21751346 0.83 CFTR (0.32) CFTRPSD
SCHEMBL30800122 0.83 CFTR (0.32) CFTRPSD
SCHEMBL19206642 0.83 KDM4E (0.32) MEN1KMT2APSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3981839-B1 COELENTERAZINE ANALOGS FOR USE IN LUCIFERASE-BASED ASSAYS PROMEGA CORP (US) 2025-08-20 — — EP disclosed
US-20240059697-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2024-02-22 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
EP-3841173-A1 COELENTERAZINE ANALOGUES Promega Corporation (US) 2021-06-30 — — EP disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed
WO-2020041579-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION (US) 2020-02-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062766-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MEN1 1826/4885F2 4526/4885C1R 4632/4885
US-11691976-B2 Coelenterazine analogues GLB1, SI, TCF7L2 MEN1 1826/4885F2 4526/4885C1R 4632/4885
US-20240059697-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MEN1 1826/4885F2 4526/4885C1R 4632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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