Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23165399 | 1.00 | SLC6A3 (0.44) | SLC6A3SLC6A2CHKAMAPTALDH1A1 | |
| SCHEMBL21751694 | 0.88 | BCL2L1 (0.51) | GAABCL2L1BCL2DRD2 | |
| SCHEMBL21751607 | 0.86 | BCL2L1 (0.51) | MAPTALDH1A1TSHRSMN1; SMN2BCL2L1 | |
| SCHEMBL23164961 | 0.86 | BCL2L1 (0.51) | MAPTALDH1A1TSHRSMN1; SMN2BCL2L1 | |
| SCHEMBL21751667 | 0.86 | BCL2L1 (0.59) | MAPTALDH1A1TSHRSMN1; SMN2BCL2L1 | |
| SCHEMBL21751641 | 0.85 | BCL2L1 (0.49) | CHKAMAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28447129 | 0.76 | BCL2L1 (0.62) | BCL2L1BCL2 | |
| SCHEMBL21751591 | 0.76 | BCL2L1 (0.62) | BCL2L1BCL2 | |
| SCHEMBL29321180 | 0.75 | BCL2L1 (0.55) | MAPTALDH1A1TSHRSMN1; SMN2GAA | |
| SCHEMBL30857624 | 0.75 | BCL2L1 (0.55) | MAPTALDH1A1TSHRSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110298-A1 | HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-01-04 | — | — | EP | disclosed |
| WO-2020041406-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |