Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 10/20 | 0.49 |
| ▸ | BCL2 | P10415 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21751667 | 0.92 | BCL2L1 (0.59) | BCL2L1BCL2MAPTALDH1A1TSHR | |
| SCHEMBL23164961 | 0.87 | BCL2L1 (0.51) | BCL2L1BCL2MAPTALDH1A1TSHR | |
| SCHEMBL21751607 | 0.87 | BCL2L1 (0.51) | BCL2L1BCL2MAPTALDH1A1TSHR | |
| SCHEMBL21751544 | 0.85 | SLC6A3 (0.44) | BCL2L1BCL2MAPTALDH1A1TSHR | |
| SCHEMBL23165399 | 0.85 | SLC6A3 (0.44) | BCL2L1BCL2MAPTALDH1A1TSHR | |
| SCHEMBL28447129 | 0.77 | BCL2L1 (0.62) | BCL2L1BCL2 | |
| SCHEMBL21751591 | 0.77 | BCL2L1 (0.62) | BCL2L1BCL2 | |
| SCHEMBL23165288 | 0.76 | BCL2L1 (0.54) | BCL2L1BCL2 | |
| SCHEMBL21751665 | 0.76 | BCL2L1 (0.54) | BCL2L1BCL2 | |
| SCHEMBL21751694 | 0.75 | BCL2L1 (0.51) | BCL2L1BCL2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115484933-A | Hot melt extrusion solid dispersions containing BCL2 inhibitors | 广州麓鹏制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2020041406-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |