Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30075016 | 1.00 | PRKCA (0.35) | PRKCAPRKCQPDPK1PARP1NPC1 | |
| SCHEMBL29722758 | 1.00 | PRKCA (0.35) | PRKCAPRKCQPDPK1PARP1NPC1 | |
| SCHEMBL30106040 | 0.90 | PRKCA (0.37) | PRKCAPRKCQPDPK1PARP1NPC1 | |
| SCHEMBL30075002 | 0.90 | PRKCA (0.37) | PRKCAPRKCQPDPK1PARP1NPC1 | |
| SCHEMBL30106037 | 0.90 | PRKCA (0.37) | PRKCAPRKCQPDPK1PARP1NPC1 | |
| SCHEMBL30364950 | 0.86 | PDPK1 (0.33) | PDPK1PARP1NPC1NUDT1CCNT1 | |
| SCHEMBL23579454 | 0.84 | OPRM1 (0.33) | PDPK1NPC1NUDT1CCNT1CCND1 | |
| SCHEMBL23165655 | 0.84 | OPRM1 (0.33) | PDPK1NPC1NUDT1CCNT1CCND1 | |
| SCHEMBL23579445 | 0.84 | OPRM1 (0.33) | PDPK1NPC1NUDT1CCNT1CCND1 | |
| SCHEMBL23579437 | 0.82 | ALOX5AP (0.34) | PDPK1NUDT1SCN9AOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110298-A1 | HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-01-04 | — | — | EP | claimed |
| CN-114929689-B | Bcl-2 inhibitors | 百济神州有限公司 | 2024-08-27 | — | — | CN | disclosed |
| EP-4110298-A1 | HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-01-04 | — | — | EP | disclosed |
| EP-4051676-A1 | BCL-2 INHIBITORS | BeiGene, Ltd. (KY) | 2022-09-07 | — | — | EP | disclosed |
| WO-2021133817-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2021-07-01 | — | — | WO | disclosed |
| WO-2020041406-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020041405-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |