Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11776410 | 0.92 | MAPT (0.66) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL28008546 | 0.88 | MAPT (0.71) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL489859 | 0.88 | ALOX15 (0.60) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL93336 | 0.87 | MAPT (0.61) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL9639006 | 0.84 | MAPT (0.65) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL4060271 | 0.82 | LMNA (0.62) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL8428996 | 0.82 | LMNA (0.51) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL7336340 | 0.82 | LMNA (0.58) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL93271 | 0.81 | MAPT (1.00) | MAPTKDM4EALOX15MAPK1HSD17B10 | |
| SCHEMBL28608000 | 0.81 | ALOX15 (0.60) | MAPTKDM4EALOX15MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109988218-B | Sarsasapogenin derivative and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-11-25 | — | — | CN | disclosed |
| CN-110121502-B | Anti-depression compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-09-23 | — | — | CN | disclosed |
| CN-106551943-B | Composition containing spirostane compound and application thereof | 中国科学院上海药物研究所 | 2021-09-10 | — | — | CN | disclosed |
| EP-3840740-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | Maggie's Pearl, LLC (US) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020040831-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | PERLARA PBC (US) | 2020-02-27 | — | — | WO | disclosed |
| CN-103183715-B | Furostan type saponin derivative and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2015-08-19 | — | — | CN | disclosed |
| CN-103183715-A | Furostan saponin derivative and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2013-07-03 | — | — | CN | disclosed |