Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776753 | 0.79 | POLB (0.39) | CHRNA7ALDH1A1POLB | |
| SCHEMBL30995324 | 0.77 | TRIM24 (0.33) | ALDH1A1TRIM24TRIM33 | |
| SCHEMBL17485615 | 0.75 | NEK2 (0.46) | — | |
| SCHEMBL18902192 | 0.74 | TRIM24 (0.35) | ALDH1A1TRIM24TRIM33 | |
| SCHEMBL30690314 | 0.74 | TRIM24 (0.36) | ALDH1A1TRIM24TRIM33 | |
| Ethylene SCHEMBL3464024 | 0.71 | TRIM24 (0.32) | ALDH1A1TRIM24TRIM33 | |
| SCHEMBL5915298 | 0.67 | CHRNA7 (0.54) | CHRNA7ALDH1A1POLB | |
| SCHEMBL9082122 | 0.67 | CRBN (0.38) | ALDH1A1POLB | |
| SCHEMBL20987576 | 0.67 | NEK2 (0.32) | CHRNA7ALDH1A1POLB | |
| SCHEMBL20987575 | 0.67 | NEK2 (0.32) | CHRNA7ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116551-B | 1-azaspiro [5.5] undecane-3-ones and 1-azaspiro [5.5] undecane-3-ols | 中国医科大学 | 2022-05-20 | — | — | CN | claimed |
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | G1 THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| CN-111116551-B | 1-azaspiro [5.5] undecane-3-ones and 1-azaspiro [5.5] undecane-3-ols | 中国医科大学 | 2022-05-20 | — | — | CN | disclosed |
| CN-111116551-B | 1-azaspiro [5.5] undecane-3-ones and 1-azaspiro [5.5] undecane-3-ols | 中国医科大学 | 2022-05-20 | — | — | CN | disclosed |
| EP-3840756-A1 | IMPROVED SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE | G1 Therapeutics, Inc. (US) | 2021-06-30 | — | — | EP | disclosed |
| CN-111116551-A | 1-azaspiro [5.5] undecan-3-ones and 1-azaspiro [5.5] undecan-3-ols | 中国医科大学 | 2020-05-08 | — | — | CN | disclosed |
| WO-2020041770-A1 | IMPROVED SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE | G1 THERAPEUTICS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | CHRNA7 2502/4885ALDH1A1 723/4885TRIM24 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.