Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25294545 | 0.75 | C1S (0.46) | HTR2AHTR2CCSNK1A1TYRO3DYRK1B | |
| SCHEMBL29786083 | 0.75 | CSNK1A1 (0.52) | HTR2AHTR2CCSNK1A1TYRO3DYRK1B | |
| SCHEMBL6582497 | 0.74 | MAPT (0.43) | KDM4EALDH1A1MAPTHPGDAKR1B1 | |
| SCHEMBL22494209 | 0.72 | AKR1B1 (0.35) | AKR1B1 | |
| SCHEMBL364480 | 0.72 | HTR6 (0.55) | HTR2AHTR2CKDM4EALDH1A1MAPT | |
| SCHEMBL27390402 | 0.71 | MEN1 (0.44) | AKR1B1 | |
| SCHEMBL25302092 | 0.70 | HTR2A (0.48) | HTR2AHTR2CKDM4EALDH1A1MAPT | |
| SCHEMBL4540142 | 0.70 | AKR1B1 (0.58) | ALDH1A1TSHRHSD17B10AKR1B1 | |
| SCHEMBL3641319 | 0.69 | ALDH1A1 (0.45) | HTR2AHTR2CKDM4EALDH1A1MAPT | |
| SCHEMBL1498169 | 0.69 | KDM4E (0.50) | HTR2AHTR2CKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841197-A1 | METHODS FOR ASSESSING TRANSENDOTHELIAL BARRIER INTEGRITY | F. Hoffmann-La Roche AG (CH) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020079107-A1 | SYNERGISTIC TRANSCRIPTION FACTORS TO INDUCE HIGH RESISTANCE TRANSENDOTHELIAL BARRIER | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020038851-A1 | METHODS FOR ASSESSING TRANSENDOTHELIAL BARRIER INTEGRITY | F. HOFFMANN-LA ROCHE AG (CH) | 2020-02-27 | — | — | WO | disclosed |