Sugi Predict

Sugi Predict / Compounds / SCHEMBL21753564

SCHEMBL21753564

SCHEMBL21753564

CCn1nc(C)c(F)c1C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 1/20 0.44
▸ ALDH1A1 P00352 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.36
▸ GAA P10253 1/20 0.36
▸ ADORA2A P29274 2/20 0.35
▸ ADORA2B P29275 2/20 0.35
▸ POLB P06746 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ APAF1 O14727 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ GRIA1 P42261 1/20 0.33
▸ GRIA2 P42262 1/20 0.33
▸ GRIA4 P48058 1/20 0.33
▸ GRIK5 Q16478 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22313546 0.84 KDM4E (0.38) NPC1ALDH1A1KDM4EGAAADORA2A
SCHEMBL22312633 0.84 KDM4E (0.35) NPC1ALDH1A1KDM4EGAAADORA2A
SCHEMBL28511363 0.83 NPC1 (0.46) NPC1ALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL17917631 0.81 ALDH1A1 (0.48) NPC1ALDH1A1KDM4EGAAADORA2A
SCHEMBL23137206 0.81 KDM4E (0.36) NPC1ALDH1A1KDM4EGAAADORA2A
SCHEMBL23116080 0.81 KMT2A (0.44) NPC1ALDH1A1KDM4EGAAPOLB
SCHEMBL105205 0.81 SMN1; SMN2 (0.38) ALDH1A1KDM4EGAAADORA2AADORA2B
SCHEMBL21753597 0.78 KDM4E (0.45) NPC1ALDH1A1KDM4EGAAADORA2A
SCHEMBL19436519 0.78 NPC1 (0.44) NPC1ALDH1A1KDM4EADORA2AADORA2B
SCHEMBL20874552 0.78 GAA (0.51) NPC1ALDH1A1KDM4EGAAADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297190-B2 Modulators of STING (stimulator of interferon genes) PFIZER INC. (US) 2025-05-13 — — US disclosed
US-20240287093-A1 HIGH ACTIVITY STING PROTEIN AGONIST ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2024-08-29 — — US disclosed
US-20240269305-A1 STING AGONIST SUITABLE AS PAYLOAD OF ANTIBODY DRUG CONJUGATE HITGEN INC (CN) 2024-08-15 — — US disclosed
CN-111655682-B High-activity STING protein agonist compound 杭州阿诺生物医药科技有限公司 2024-05-31 — — CN disclosed
EP-3842437-B1 HIGH ACTIVITY STING PROTEIN AGONIST ADLAI NORTYE BIOPHARMA CO LTD (CN) 2024-04-10 — — EP disclosed
CN-111386275-B High activity STING protein agonists 杭州阿诺生物医药科技有限公司 2023-03-10 — — CN disclosed
EP-4034534-A1 POLYHETEROCYCLIC MODULATORS OF STING (STIMULATOR OF INTERFERON GENES) Pfizer Inc. (US) 2022-08-03 — — EP disclosed
CN-114728946-A Polyheterocyclic modulators of STING (stimulator of interferon genes) 辉瑞公司 2022-07-08 — — CN disclosed
CN-112552314-B Small-molecule anti-tumor compound of STING agonist and application thereof 杭州阿诺生物医药科技有限公司 2022-03-04 — — CN disclosed
EP-3848366-A1 HIGHLY ACTIVE STING PROTEIN AGONIST COMPOUND Adlai Nortye Biopharma Co., Ltd. (CN) 2021-07-14 — — EP disclosed
CN-112552314-A Small-molecule anti-tumor compound of STING agonist and application thereof 杭州阿诺生物医药科技有限公司 2021-03-26 — — CN disclosed
US-20210087180-A1 Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2021-03-25 — — US disclosed
US-20210087180-A1 Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2021-03-25 — — US disclosed
CN-111655682-A High-activity STING protein agonist compound 杭州阿诺生物医药科技有限公司 2020-09-11 — — CN disclosed
WO-2020156363-A1 IMMUNOMODULATOR 成都先导药物开发股份有限公司 2020-08-06 — — WO disclosed
WO-2020156363-A1 IMMUNOMODULATOR 成都先导药物开发股份有限公司 2020-08-06 — — WO disclosed
CN-111386275-A High activity STING protein agonists 杭州阿诺生物医药科技有限公司 2020-07-07 — — CN disclosed
WO-2020042995-A1 HIGHLY ACTIVE STING PROTEIN AGONIST COMPOUND 杭州阿诺生物医药科技有限公司 2020-03-05 — — WO disclosed
WO-2020038387-A1 HIGH ACTIVITY STING PROTEIN AGONIST 杭州阿诺生物医药科技有限公司 2020-02-27 — — WO disclosed
WO-2020038387-A1 HIGH ACTIVITY STING PROTEIN AGONIST 杭州阿诺生物医药科技有限公司 2020-02-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287093-A1 HIGH ACTIVITY STING PROTEIN AGONIST STING1, IRF3, MAVS NPC1 541/4885ALDH1A1 4763/4885KDM4E 3778/4885
US-12297190-B2 Modulators of STING (stimulator of interferon genes) STING1, IRF3, CGAS NPC1 2332/4885ALDH1A1 4800/4885KDM4E 3785/4885
US-20240269305-A1 STING AGONIST SUITABLE AS PAYLOAD OF ANTIBODY DRUG CONJUGATE STING1, TBK1, CGAS NPC1 2082/4885ALDH1A1 4740/4885KDM4E 2389/4885
US-20210087180-A1 Modulators of STING (Stimulator of Interferon Genes) STING1, IRF3, CGAS NPC1 2332/4885ALDH1A1 4800/4885KDM4E 3785/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.