Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753616 | 0.90 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL21753632 | 0.84 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL28364642 | 0.82 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL21753656 | 0.82 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL28883960 | 0.81 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL21753629 | 0.80 | P2RY1 (0.51) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL21753619 | 0.80 | NTRK1 (0.50) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL28884502 | 0.79 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL28361113 | 0.78 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1ATMNTRK1LMNA | |
| SCHEMBL25285702 | 0.78 | NTRK1 (0.43) | ALDH1A1L3MBTL1ATMNTRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11692004-B2 | Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof | JIANGSU VANGUARD PHARMACEUTICAL CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
| CN-110857285-B | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 江苏万高药业股份有限公司 | 2022-12-20 | — | — | CN | disclosed |
| US-20220372058-A1 | Substituted Pyrazole Compound, Preparation Method Therefor, Pharmaceutical Composition and Medical Use Thereof | JIANGSU VANGUARD PHARMACEUTICAL CO., LTD (CN) | 2022-11-24 | — | — | US | disclosed |
| CN-110857285-A | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 天津谷堆生物医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| WO-2020038279-A1 | SUBSTITUTED PYRAZOLE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | 天津谷堆生物医药科技有限公司 | 2020-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372058-A1 | Substituted Pyrazole Compound, Preparation Method Therefor, Pharmaceutical Composition and Medical Use Thereof | FARS2, GOT2, HADHB | ALDH1A1 2197/4885L3MBTL1 1066/4885ATM 2497/4885 |
| US-11692004-B2 | Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof | FARS2, GOT2, HADHB | ALDH1A1 2197/4885L3MBTL1 1066/4885ATM 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.