Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.63 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.47 |
| ▸ | PTGFR | P43088 | 3/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441915 | 0.88 | ALDH1A1 (0.64) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL6441918 | 0.88 | ALDH1A1 (0.64) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL11620081 | 0.88 | ALDH1A1 (0.64) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL16613944 | 0.86 | PDE4D (0.61) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL12363806 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL16613913 | 0.84 | PTGFR (0.59) | ALDH1A1TBXA2RPTGER1PTGFRPTGER3 | |
| SCHEMBL11789450 | 0.82 | ALDH1A1 (0.63) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8903403 | 0.82 | ALDH1A1 (0.76) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8901625 | 0.82 | ALDH1A1 (0.76) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8901630 | 0.82 | ALDH1A1 (0.76) | ALDH1A1KDM4EHKDC1TDP1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11185538-B2 | Compositions for treating glaucoma or reducing intraocular pressure | AERIE PHARMACEUTICALS, INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20210244722-A1 | COMPOSITIONS FOR TREATING GLAUCOMA OR REDUCING INTRAOCULAR PRESSURE | ALCON INC. (CH) | 2021-08-12 | — | — | US | disclosed |
| US-11020385-B2 | Combination therapy | AERIE PHARMACEUTICALS, INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200129498-A1 | COMBINATION THERAPY | ALCON INC. (CH) | 2020-04-30 | — | — | US | disclosed |
| US-10568878-B2 | Combination therapy | AERIE PHARMACEUTICALS, INC. (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11020385-B2 | Combination therapy | PTGS1, PTGS2, PTGIS | ALDH1A1 1638/4885KDM4E 4416/4885HKDC1 3422/4885 |
| US-11185538-B2 | Compositions for treating glaucoma or reducing intraocular pressure | PTGS1, PTGIS, PTGS2 | ALDH1A1 2068/4885KDM4E 3724/4885HKDC1 2857/4885 |
| US-20200129498-A1 | COMBINATION THERAPY | PTGS1, PTGS2, PTGIS | ALDH1A1 1638/4885KDM4E 4416/4885HKDC1 3422/4885 |
| US-20210244722-A1 | COMPOSITIONS FOR TREATING GLAUCOMA OR REDUCING INTRAOCULAR PRESSURE | PTGS1, PTGIS, PTGS2 | ALDH1A1 2068/4885KDM4E 3724/4885HKDC1 2857/4885 |
| US-10568878-B2 | Combination therapy | PTGS1, PTGS2, PTGIS | ALDH1A1 1611/4885KDM4E 4357/4885HKDC1 3526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.