Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.30 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21755840 | 0.85 | ALDH1A1 (0.34) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL18630392 | 0.83 | RAB9A (0.43) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15088077 | 0.77 | ALDH1A1 (0.39) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30078009 | 0.77 | ALDH1A1 (0.39) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL21755841 | 0.75 | ERN1 (0.32) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15065865 | 0.74 | ERN1 (0.47) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30078010 | 0.73 | TRIM24 (0.42) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15066133 | 0.73 | TRIM24 (0.42) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL21755834 | 0.73 | ERN1 (0.32) | ALDH1A1ERN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL21755837 | 0.73 | PTGDR2 (0.34) | ALDH1A1MAPTSMN1; SMN2NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-B1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |