Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23240355 | 0.86 | SMN1; SMN2 (0.45) | CYP2C19ALDH1A1MAPK1CYP3A4HIF1A | |
| SCHEMBL5986519 | 0.84 | OPRM1 (0.54) | OPRM1OPRL1CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL21756986 | 0.84 | GRM5 (0.37) | OPRM1OPRL1CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL20144252 | 0.83 | CYP2C19 (0.42) | OPRM1OPRL1CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL16852620 | 0.80 | CYP3A4 (0.53) | OPRM1OPRL1CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL23707472 | 0.79 | SMN1; SMN2 (0.42) | CYP2C19ALDH1A1MAPK1CYP3A4HIF1A | |
| SCHEMBL6233534 | 0.79 | CYP3A4 (0.51) | OPRM1OPRL1CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL23763347 | 0.79 | CYP1A2 (0.52) | OPRM1OPRL1CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL21757045 | 0.77 | EPHX2 (0.45) | OPRM1OPRL1CYP2C19CYP2C9GRM5 | |
| SCHEMBL21757048 | 0.76 | JAK1 (0.45) | OPRM1OPRL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022161205-A1 | ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2022-08-04 | — | — | WO | disclosed |
| WO-2021159372-A1 | USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES | 珠海联邦制药股份有限公司 | 2021-08-19 | — | — | WO | disclosed |
| EP-3842431-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND APPLICATION THEREOF | Zhuhai United Laboratories Co., Ltd (CN) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020038457-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2020-02-27 | — | — | WO | disclosed |