Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21759173 | 0.93 | POLB (0.76) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL6027881 | 0.90 | POLB (0.81) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL13866493 | 0.90 | POLB (0.81) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL21759172 | 0.86 | POLB (0.71) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL5884965 | 0.86 | POLB (0.71) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL20050150 | 0.85 | POLB (0.62) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL20050081 | 0.82 | ABCB1 (0.67) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL21759061 | 0.82 | POLB (0.61) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL12122811 | 0.80 | POLB (0.63) | POLBALDH1A1MAPTMAPK1GAA | |
| SCHEMBL25584188 | 0.80 | POLB (0.60) | POLBALDH1A1MAPTMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673853-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673853-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-06-13 | — | — | US | disclosed |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS TECHNOLOGY TRANSFER PROGRAM (10P9TT) | 2022-05-19 | — | — | US | disclosed |
| US-11040935-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200062693-A1 | SMALL MOLECULE AMPK ACTIVATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673853-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | POLB 3111/4885ALDH1A1 2770/4885MAPT 2764/4885 |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | PRKAG1, PRKAG2, PRKAA1 | POLB 3111/4885ALDH1A1 2770/4885MAPT 2764/4885 |
| US-11040935-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | POLB 3111/4885ALDH1A1 2770/4885MAPT 2764/4885 |
| US-20200062693-A1 | SMALL MOLECULE AMPK ACTIVATORS | PRKAG1, PRKAG2, PRKAA1 | POLB 3111/4885ALDH1A1 2770/4885MAPT 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.