Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.67 |
| ▸ | TGFBR2 | P37173 | 9/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21759080 | 0.86 | TGFBR1 (0.69) | TGFBR1TGFBR2 | |
| SCHEMBL18041506 | 0.84 | TGFBR1 (0.81) | TGFBR1TGFBR2 | |
| SCHEMBL21759288 | 0.84 | TGFBR1 (0.72) | TGFBR1TGFBR2 | |
| SCHEMBL21759250 | 0.83 | TGFBR1 (0.71) | TGFBR1TGFBR2 | |
| SCHEMBL21759213 | 0.82 | TGFBR1 (0.73) | TGFBR1TGFBR2 | |
| SCHEMBL21748160 | 0.81 | TGFBR1 (0.82) | TGFBR1TGFBR2 | |
| SCHEMBL21759216 | 0.81 | TGFBR1 (0.71) | TGFBR1TGFBR2 | |
| SCHEMBL21759127 | 0.81 | TGFBR1 (0.71) | TGFBR1TGFBR2 | |
| SCHEMBL18042038 | 0.81 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18042084 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265454-B1 | TGF-BETA INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2020-02-26 | — | — | EP | disclosed |