SCHEMBL21759463

SCHEMBL21759463

O=C1CCC(N2C(=O)c3ccc(CBr)cc3C2=O)C(=O)N1

nearest known ligand 0.70

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 18/20 0.70
DDB1 Q16531 13/20 0.70
ALDH1A1 P00352 1/20 0.66
CHRM2 P08172 1/20 0.66
OPRM1 P35372 1/20 0.66
IKZF3 Q9UKT9 1/20 0.66
CYP1A2 P05177 1/20 0.66
TSHR P16473 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
IKZF1 Q13422 1/20 0.54
IKZF2 Q9UKS7 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25231125 0.88 CRBN (0.68) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL15128667 0.87 CRBN (0.69) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL4450513 0.87 CRBN (0.70) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL29439978 0.87 CRBN (0.70) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL23945409 0.87 CRBN (0.69) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL25272337 0.87 CRBN (0.70) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL23806450 0.87 CRBN (0.69) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL25238600 0.87 CRBN (0.67) CRBNDDB1ALDH1A1CHRM2OPRM1
SCHEMBL31125239 0.87 CRBN (0.70) CRBNDDB1ALDH1A1CHRM2OPRM1
Hydrochloric Acid SCHEMBL1415225 0.86 CRBN (0.65) CRBNDDB1ALDH1A1CHRM2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
US-20260021095-A1 BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS INC (US) 2026-01-22 US disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
US-20250367193-A1 BIFUNCTIONAL COMPOUNDS CONTAINING SUBSTITUTED PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS INC (DE) 2025-12-04 US disclosed
WO-2025235298-A1 BIFUNCTIONAL COMPOUNDS CONTAINING THIAZOLYL DERIVATIVES FOR DEGRADING CERTAIN CYCLIN-DEPENDENT KINASE VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS, INC. (US) 2025-11-13 WO disclosed
WO-2025235331-A1 BIFUNCTIONAL COMPOUNDS CONTAINING PYRAZOLOPYRIMIDINE DERIVATIVES FOR DEGRADING CERTAIN CYCLIN-DEPENDENT KINASE VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS, INC. (US) 2025-11-13 WO disclosed
WO-2025235261-A1 BIFUNCTIONAL COMPOUNDS CONTAINING 2,4,5-SUBSTITUTED PYRIMIDINE DERIVATIVES FOR DEGRADING CERTAIN CYCLIN-DEPENDENT KINASE VIA UBIQUITIN PROTEASOME PATHWAY NIKANG THERAPEUTICS, INC. (US) 2025-11-13 WO disclosed
EP-4615833-A1 BIFUNCTIONAL COMPOUNDS CONTAINING 2,5-SUBSTITUTED PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY Nikang Therapeutics, Inc. (US) 2025-09-17 EP disclosed
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2025-09-09 US disclosed
WO-2022073469-A1 COMPOUNDS AND METHODS OF TREATING CANCERS CULLGEN (SHANGHAI) , INC. (CN) 2022-04-14 WO disclosed
WO-2022073469-A1 COMPOUNDS AND METHODS OF TREATING CANCERS CULLGEN (SHANGHAI) , INC. (CN) 2022-04-14 WO disclosed
WO-2022068933-A1 COMPOUNDS AND METHODS OF TREATING DISEASES CULLGEN (SHANGHAI) , INC. (CN) 2022-04-07 WO disclosed
WO-2022019597-A1 COMPOUND FOR ANDROGEN RECEPTOR DEGRADATION, AND PHARMACEUTICAL USE THEREOF 주식회사 유빅스테라퓨틱스 2022-01-27 WO disclosed
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-11-25 US disclosed
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-10-14 US disclosed
CN-112888681-A Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use 上海睿跃生物科技有限公司 2021-06-01 CN disclosed
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 WO disclosed
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 WO disclosed
WO-2020038415-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2020-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260021095-A1 BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY PSMB2, PSMB7, MDM2 CRBN 85/4885DDB1 197/4885ALDH1A1 3471/4885
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, ERBB2, NTRK1 CRBN 330/4885DDB1 480/4885ALDH1A1 4113/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 CRBN 149/4885DDB1 1222/4885ALDH1A1 4483/4885
US-20250367193-A1 BIFUNCTIONAL COMPOUNDS CONTAINING SUBSTITUTED PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY CDK2, SKP2, CCNK CRBN 402/4885DDB1 376/4885ALDH1A1 3087/4885
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, NTRK1, ERBB2 CRBN 194/4885DDB1 418/4885ALDH1A1 3928/4885
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 CRBN 330/4885DDB1 480/4885ALDH1A1 4113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.