Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 5/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981009 | 0.89 | ACVR1 (0.39) | ARMAPK8PGRFAAHPDE4A | |
| SCHEMBL9980942 | 0.79 | METAP2 (0.50) | ARMAPK8PGRAKT1FAAH | |
| SCHEMBL9980966 | 0.79 | PDE4A (0.39) | ARMAPK8PGRFAAHPDE4A | |
| SCHEMBL9981039 | 0.76 | MAPK8 (0.45) | ARMAPK8PGRAKT1FAAH | |
| SCHEMBL9981138 | 0.74 | METAP2 (0.39) | ARMAPK8PGRAKT1FAAH | |
| SCHEMBL9981438 | 0.74 | PGR (0.48) | ARMAPK8PGRFAAHPDE4A | |
| SCHEMBL15379959 | 0.73 | FAAH (0.37) | ARMAPK8PGRFAAHPDE10A | |
| SCHEMBL1701308 | 0.73 | KDM4E (0.52) | ARMAPK8PGRFAAHPDE4A | |
| SCHEMBL9980899 | 0.72 | AR (0.45) | ARMAPK8PDE4APDE4BPDE4C | |
| SCHEMBL9980990 | 0.70 | PDE10A (0.44) | PDE4BPDE10AMEN1POLBPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |